Stickler syndrome, a hereditary connective tissue disorder caused by mutations in collagen genes, has a wide variety of clinical manifestations. Currently, knowledge is lacking about otological and orofacial characteristics. In this study, we want to gain insight in this, as well as a better understanding of the molecular background and pathogenesis on hearing loss and cleft palate of Stickler syndrome.
Functional importance and genetics of common developmental osteoarticular abnormalities in sport horses Ghent University
Osteo-articular problems and lameness are a major threat for the athletic career of sporthorses. Therefore, it has become routine to screen youngsters radiographically for developmental osteo-articular abnormalities (DOAs). The results of this screening largely influence the economic value of the horse and determines whether it is suitable for breeding. However, there is ongoing debate which specific DOAs indeed have a functional impact. ...
Bridging the gap between genotype and phenotype: a working example on the effect of cell wall-related enzymes and drought stress on yield in wheat Ghent University
Recent developments in several omics platforms have made it possible to generate huge amounts
of genetic data. However, when trying to unravel how a genotype translates into a phenotype,
research often returns to traditional and laborious methods, and GxE interaction remains difficult
to detect. Ecophysiological models can quantify the effect of an environment on a phenotype, but
incorporation of genetic data within these ...
The Belgian prenatal microarray database (BEMAPRE): realization of the database, determination of genotype-phenotype correlations and postnatal follow-up. University of Antwerp
Lessons from pseudo(pseudo)hypoparathyroidism using platelets: (epi)genetic defects within and outside the imprinted GNAS cluster. KU Leuven
GNAS is an imprinted region that gives rise to several transcripts, including transcription of the alpha subunit of the stimulatory G protein (Gsalpha). The complexity of the GNAS cluster results in ubiquitous and tissue-specific genomic imprints and in multiple genotype-phenotype relationships. Phenotypes resulting from genetic and epigenetic abnormalities of GNAS include Albright Hereditary Osteodystrophy (AHO), ...
The Biomark Microfluidics system for high throughput genotyping, expression profiling and CNV analysis. University of Antwerp
Freshwater ecosystems are hotspots of microbial biogeochemical processes and both their biodiversity and function are currently threatened by global change. As the composition of microbial communities rapidly alters when subjected to environmental change, it is important to understand how these structural changes translate into functional changes. To achieve this deeper understanding, this research project will study the observable ...
Combined effects of drought stress and inbreeding on epigenetic inheritance and adaptive potential KU Leuven
Ongoing climate change and habitat fragmentation are among the most important threats to species and community persistence. The adaptive potential of species, and therefore their ability to cope with global environmental threats, is assumed to mainly depend on genetic variation underlying quantitative trait variation. However, recent advances in molecular ecology suggest an important role for epigenetic inheritance in adaptive ecological ...