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Inter-individual variation in the physiological adaptations to hypoxia KU Leuven

Martine Thomis
Abdominal Transplantation, Physical Activity, Sports & Health Research Group, Exercise Physiology Research Group
This PhD research project aimed to explore some factors underlying the large inter-individual differences in physiological responses to hypoxia. Despite many investigations, assessment of hypoxic tolerance in healthy individuals is difficult and research fails to predict and differentiate well vs.</> poor responders. This PhD research partly answered this question by providing evidence of an individuals genetic potential to tolerate ...

The role of the microbiome in eco-evo feedbacks in natural settings KU Leuven

Ellen Decaestecker
Ecology, Evolution and Biodiversity Conservation, Biology, Kulak Kortrijk Campus

Rising water temperatures and increasing eutrophication are disrupting the well-functioning of our aquatic systems, amongst others stimulating the growth of toxic cyanobacterial blooms. These blooms pose an important threat to human health, drinking water supplies, livestock, recreational activities, ecosystem functioning and food web structure. Daphnia spp. are pivotal interactors in pond and lake ecosystems, and their strong grazing ...

The development of transgene Daphnia in a molecular reconstruction of a host-parasite coevolution. KU Leuven

Ellen Decaestecker
Biology, Kulak Kortrijk Campus
Antagonistic interactions between hosts and parasites are a key structuring force in natural host populations leading to coevolution. The omnipresence of parasites in combination with their short generation time and their virulence effects, enables parasites to reduce the density and to influence the genetic structure of their host populations. In the arms race with their fast evolving parasites, there will be selection in the host against ...

Kino2omics integration platform bridging the Genotype and Phenotype gap in medical research. University of Antwerp

Wim Vanden Berghe
Center for Oncological Research (CORE), Proteinscience, proteomics and epigenetic signaling (PPES)
Protein phosphorylation is a reversible post-translational modification playing a crucial role in controlling the functional state of proteins in health and disease. Profiling protein kinase activity has become a critical component in molecular clinical biology precision medicine and constitutes a promising tool for drug discovery. However, current strategies can monitor only single kinases or imply complex procedures and infrastructure ...

Xenotransplantation of genetically engineered iPSC-derived microglia and neurons to decipher the cell-type specific interplay of Progranulin and TMEM106B in neuroinflammation and neurodegeneration. University of Antwerp

VIB CMN - Microglia and Inflammation in Neurological Disorders (MIND) lab, VIB CMN - Applied and Translational Neurogenomics
Frontotemporal lobar degeneration (FTLD) is an early-onset form of dementia representing 10-20% of all dementia cases. It is characterized by the loss of neurons in the frontal and temporal lobes resulting in a dramatic impact on core human qualities including personality, insight and verbal communication. Aggregates of the TAR DNA-binding protein 43 (TDP-43) are the hallmark of the most common pathological subtype of FTLD (FTLD-TDP). ...

On a spicy journey: In search of climate resilient vanilla production systems KU Leuven

Bart Muys
Forest, Nature and Landscape
Climate change is predicted to severely affect the agricultural sector, and diversification at both crop genetic and system level is vital in the development of climate resilient agro-systems. The tropical cash crop vanilla is facing a number of threats that are jeopardizing its future supply. Being an important crop for many smallholder farmers around the tropics and a highly appreciated spice used in a range of products, there is an urgent ...

Assessing genetic and phenotypic diversity of Brettanomyces yeast KU Leuven

Bart Lievens, Kathleen Marchal
Bioengineering Technology, Group T Leuven Campus, Computer Science Technology, De Nayer (Sint-Katelijne-Waver) Campus, Centre of Microbial and Plant Genetics

Brettanomyces yeast species, with Brettanomyces (Dekkera) bruxellensis being the most important, are generally reported to be spoilage yeasts in the beer and wine industry due to the production of phenolic off-flavors. The aromas imparted, which can be described as ‘medicinal and ‘barnyard’, are colloquially known as “Brett” character and are generally considered negative for beer and wine quality. However, ...