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Precision medicine: integration of genetics and functional genomics in prediction of bronchiolitis obliterans after lung transplantation KU Leuven
PURPOSE OF REVIEW: Lung transplantation (LTx) can be a life saving treatment in end-stage pulmonary diseases, but survival after transplantation is still limited. Posttransplant development of chronic lung allograft dysfunction with bronchiolits obliterans syndrome (BOS) as the major subphenotype, is the main cause of morbidity and mortality. Early identification of high-risk patients for BOS is a large unmet clinical need. In this review, we ...
Tailoring the American College of Medical Genetics and Genomics and the Association for Molecular Pathology guidelines for the interpretation of sequenced variants in the FBN1 gene for Marfan syndrome : proposal for a disease- and gene-specific guideline Vrije Universiteit Brussel Ghent University
Background: The introduction of next-generation sequencing techniques has substantially increased the identification of new genetic variants and hence the necessity of accurate variant interpretation. In 2015, the American College of Medical Genetics and Genomics and the Association for Molecular Pathology proposed new variant interpretation guidelines. Gene-specific characteristics were, however, not considered, sometimes leading to ...
Editorial overview: Genome studies and molecular genetics : of plant genes, genomes, and genomics Ghent University
Species' ranges and the genetics and genomics of recent range expansion in Coenagrion damselflies KU Leuven
Many ectothermic species are currently expanding their geographic rangepolewards, which makes for exciting natural evolutionary experiments and offers unique opportunities to study evolutionary processes related tospecies ranges. The factors that ultimately determine range sizes, range limits and their dynamics are key issues in ecology and evolution. Inthis study we aimed to shed a light on the drivers of range size acrossthe different species ...
Genetics of Inflammatory Bowel Disease: How Modern Genomics Informs Basic, Clinical and Translational Science KU Leuven
Lessons which can be learned: It is clear that the research on IBD genetics has proven to be one of the mostsuccessful of all complex polygenic traits. Both linkage and association scans have identified many genes and the firstconclusion is that these genes can be grouped into biological pathways (see Figure 4.4). New pathways (for instanceautophagy) have been identified, which need to be explored, and other pathways (role of barrier integrity ...
How functional genomics and genetics complements insect endocrinology KU Leuven
Insects are the most abundant animal group on Earth and have been the subject of genetic and physiological studies since the beginning of the 19th century. The public interest in understanding their biology increased as many insects have proven to exert a severe impact on human welfare and the environment. To trigger insect physiological and endocrinological research, the genome of several economical and ecological important insect species was ...
Are You AI’S Favourite? EU Legal Implications of Biased AI Systems in Clinical Genetics and Genomics Vrije Universiteit Brussel
The article provides a legal overview of biased AI systems in clinical genetics and genomics. For the overview, two perspectives to look at bias are taken into consideration: societal and statistical. The paper explores how biases can be defined in these two perspectives and how generally they can be classified. Based on two perspectives, the paper explores three negative consequences of biases in AI systems: discrimination and stigmatization ...