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Surpassing the mechanical boundaries of crosslinkable gelatin Ghent University
INTRODUCTION: The present work aims to develop gelatin hydrogels with tunable mechanical properties which reach beyond the capabilities of currently applied methacrylamide modified gelatin (gel-MOD) materials. To this end, both the primary amines as well as the carboxylic acids in the gelatin backbone will be functionalized with crosslinkable moieties followed by crosslinking via UV irradiation. MATERIALS AND METHODS: In a first part, the free ...
Gelatin Electrospun Mat as a Potential Co-culture System for In Vitro Production of Sperm Cells from Embryonic Stem Cells Vrije Universiteit Brussel
Engineering of 3D substrates with maximum similarity to seminiferous tubules would help to produce functional sperm cells in vitro from stem cells. Here, we present a 3D electrospun gelatin (EG) substrate seeded with Sertoli cells and determine its potential for guided differentiation of embryonic stem cells (ESCs) toward germline cells. The EG was fabricated by electrospinning, and its morphology under SEM, as well as cytobiocompatibility ...
Quantitative contrasts in the photopolymerization of acrylamide and methacrylamide-functionalized gelatin hydrogel building blocks Ghent University
Synergistic effect of κ-carrageenan and gelatin blends towards adipose tissue engineering Ghent University
Indirect additive manufacturing as an elegant tool for the production of self-supporting low density gelatin scaffolds Vrije Universiteit Brussel Ghent University
The present work describes for the first time the production of self-supporting low gelatin density (<10 w/v%) porous scaffolds using methacrylamide-modified gelatin as an extracellular matrix mimicking component. As porous scaffolds starting from low gelatin concentrations cannot be realized with the conventional additive manufacturing techniques in the abscence of additives, we applied an indirect fused deposition modelling approach. To ...
Thiol-norbornene gelatin hydrogels : influence of thiolated crosslinker on network properties and high definition 3D printing Ghent University Vrije Universiteit Brussel
Photocrosslinkable gelatin hydrogels are excellent bioinks or biomaterial ink components to serve biofabrication applications. Especially the widely investigated gelatin-methacroyl (gel-MA) hydrogels hold an impressive track record. However, over the past decade, increasing attention is being paid to thiol-ene photo-click chemistry to obtain hydrogel networks benefitting from a faster reactivity (i.e. seconds vs minutes) along with superior ...
Gelatin functionalization of biomaterial surfaces : strategies for immobilization and visualization Ghent University
In the present work, the immobilization of gelatin as biopolymer on two types of implantable biomaterials, polyimide and titanium, was compared. Both materials are known for their biocompatibility while lacking cell-interactive behavior. For both materials, a pre-functionalization step was required to enable gelatin immobilization. For the polyimide foils, a reactive succinimidyl ester was introduced first on the surface, followed by covalent ...