Publications
Development of a Core Outcome Set for Children Aged 1-18 Years with Gastroesophageal Reflux Disease Vrije Universiteit Brussel
Objective: To develop a core outcome set for clinical studies assessing gastroesophageal reflux disease (GERD) in children. Study design: This core outcome set was developed using a 2-round Delphi technique and adhering to the Outcome Measures in Rheumatology Initiative (OMERACT 2.0) recommendations. Healthcare professionals (HCPs) and (parents of) children (age 1-18 years) with a GERD diagnosis (ie, the presence of bothersome symptoms), ...
The Gastroesophageal Reflux Disease Questionnaire in Adolescents Vrije Universiteit Brussel
Background: A self-assessment questionnaire, the GERD-Questionnaire (GERD-Q) was used to determine the prevalence of GERD in adolescents, describe the related factors, and determine the impact on quality of life (QoL).
Methods: The incidence of GERD was evaluated using the GERD-Q in adolescents aged 12-18 years. The Pediatric Gastroesophageal Reflux Disease Symptom Questionnaire and Quality of Life Questionnaire (PGSQ-A) for ...
Safety and Tolerability of Esomeprazole in Children With Gastroesophageal Reflux Disease Vrije Universiteit Brussel
OBJECTIVES: To evaluate safety, tolerability, and symptom improvement with once-daily esomeprazole in children with endoscopically proven gastroesophageal reflux disease (GERD).
PATIENTS AND METHODS: In this 8-week, multicenter, randomized, uncontrolled, double-blind study, children ages 1 to 11 years were stratified by weight to receive esomeprazole 5 or 10 mg (children < 20 kg) or 10 or 20 mg (children ≥ 20 kg) once daily. Safety ...
Infant regurgitation and pediatric gastroesophageal reflux disease Vrije Universiteit Brussel
Infant regurgitation and pediatric gastroesophageal reflux disease Vrije Universiteit Brussel
Diagnosis of gastroesophageal reflux disease Vrije Universiteit Brussel
The diagnosis of gastroesophageal reflux disease (GERD) remains a challenge. The symptoms and manifestations caused by GERD vary from nonerosive reflux disease over Barrett's esophagus to chronic respiratory disease. As a consequence, it is clear that not one investigation technique will provide an answer in all situations. Although many diagnostic techniques are available, most of them are not needed to diagnose GERD. Upper gastrointestinal ...
Impact of antisecretory treatment on respiratory symptoms of gastroesophageal reflux disease in children. Vrije Universiteit Brussel
Regurgitation and gastroesophageal reflux disease in six to nine months old Indonesian infants Vrije Universiteit Brussel
Purpose: Regurgitation is known to peak at the age of 3-4 months, with a sharp decrease around the age of 6 months. Little is known about the natural evolution of infants who still regurgitate after the age of 6 months. Methods: Hundred thirty-one infants older than 6 months regurgitating more than once a day were followed for a period of 3 months. Results: According to our data, gastroesophageal reflux disease (GERD) is seldom at this age. ...