Mechanisms of symptom generation and symptom perception in typical and atypical manifestiations of gastroesophageal reflux disease. KU Leuven
Gastroesophageal reflux (GER) is the retrograde flow of gastric contents into the esophagus and can be accompanied by typical symptoms, like heartburn and regurgitation. Treatment with acid suppressive therapy is highly effective in healing esophageal lesions. However, a large proportion of GER patients continues to have symptoms. Since the exact mechanisms behind these remaining symptoms are not yet elucidated, effective treatment modalities ...