Projects
Metabolic syndrome in bipolar disorder: relationships with physical activity, physical fitness and functional exercise capacity. KU Leuven
Individuals with mood disorders have a high risk for cardiovascular diseases. The lack of physical activity and a limited physical fitness are known to be important risk factors for cardiovascular diseases. Individuals with mood disorders should therefore especially be motivated to adopt an active lifestyle. In order to offer clear guidelines, there is first need for reliable assessment. In this research project we want to evaluate the ...
Microenvironmental Conditions to Support Formation of Metabolically Adequate Functional Beta Cell Mass by Human Islet Cell implants in the Omentum of Type 1 Diabetes Patients Vrije Universiteit Brussel
pancreas. The disease can be treated by insulin administration but
not cured. Replacement of the beta cell mass has the potential of a
cure if it establishes a metabolically adequate function. Intraportal
implants of islet cell isolates from donor pancreases can restore a
physiologically regulated insulin provision, but its functional beta cell
...
Development of an innovative hiPSC-derived cardiac-microtissue-based functional assay to determine the pathogenicity of genetic variants with uncertain significance identified in patients with inherited cardiac arrhythmia; University of Antwerp
Functional analysis of drought tolerance promoting endophytes in the growth zone of maize leaves. University of Antwerp
Tracking the biological fate of functional colloids in situ and in living cells KU Leuven
The use of nanotechnology in cancer therapy has attracted growing attention over the past decade. Many drug nanocarriers offering considerable advantages over conventional chemotherapy have been developed. Although binding strength and selectivity of nanocarriers with cell membranes can be controlled and has been investigated, the selective interaction with membrane receptors in e.g. drug delivery builds upon a sequence of steps, ranging from ...
Structural and functional brain effects of prenatal spina bifida fetal repair KU Leuven
Spina bifida (SB) is one of the most frequent malformations occurring in fetal central nervous system and it is correlated with several complications. Neurological impairments as lower cognition level and structural brain abnormalities as midbrain herniation and hydrocephalus have already been described over the past years. Currently, different surgical techniques have been tested aiming to achieve a better maternal and fetal outcome, ...
Social isolation in adolescent AD mice: effects on behaviour and functional connectivity KU Leuven
Adolescent transgenic mice with Alzheimer’s disease (AD) will be separated into two groups at random: standard housing and social isolation (SI). In addition, wild-type mice will also be randomly separated into a standard housing and isolation group. Each of the four groups will be tested as outlined below. We expect that SI to exacerbate AD-like symptoms in transgenic mice (see e.g. Huang et al., 2015; Hui, Feng, Zheng, Jin, and Jia, 2017). ...
An integrated functional proteomics platform for the study of normal development and disease Ghent University
The decoding of the human genome has greatly facilitated sequencing, gene expression and protein high-throughput studies. This implies however major challenges towards data validation, not in the least at the individual protein level of selected targets. This demands the testing and optimization of protein antibodies and further testing on patient samples and cellular model systems used in the lab. This part is a major bottle neck and ...
SUBJECT-SPECIFIC GRAPH MEASURES BASED ON RESTING-STATE FUNCTIONAL MRI AS POTENTIAL BIOMARKERS FOR ALZHEIMER’S DISEASE KU Leuven
The brain is one of the most complex systems. To understand the brain we have to understand how the brain works, in terms of how remote/non-remote brain regions effectively interact and how brain regions are organized to process information. Therefore, it is important to understand the brain as a network. To quantify the performance of brain networks, graph theory is a very suitable method. It has been proposed that graph measures of ...