Projects
Correlation between (changes in) functional beta cell mass and islet autoantibodies in (pre)type 1 diabetes with or without immune intervention Vrije Universiteit Brussel
Integration of high-throughput approaches to link culturable microbial diversity and metabolic potential in traditional fermented foods: a new screening strategy for functional starter cultures Ghent University
Traditional fermented foods are appreciated by the consumer for their organoleptic and health promoting characteristics. In such products it is often unclear which microorganisms and metabolites are responsible for their characteristics. The present project aims to develop and validate a new stategy to analyse this microbiological and metabolic potential more efficently in order to develop functional starter cultures with applications in food ...
Integration of high-throughput approaches to link culturable microbial diversity with metabolic potential in traditional fermented foods: towards a new strategy for functional starter culture screening Vrije Universiteit Brussel
Alterations in mitochondrial biogenesis and function-a link between metabolic adaptation and contractile dysfunction in chronic ischemic heart disease. KU Leuven
Peroxisomes in mast cells – their functions and link to airway inflammation Ghent University
This project will focus on peroxisomal functions and their involvement in inflammatory processes in the
context of chronic rhinosinusitis. The emphasis on the investigations will be put on the peroxisomes of mast
cells. The experiments will be done on human ex vivo nasal tissue and murine models.
Identification of endotrophin as the link between autophagy deficiency and changes in vascular smooth muscle cell function. University of Antwerp
Regulation of skeletal muscle function by a new link between mechanosensors and metabolism. KU Leuven
Skeletal muscle (SkM) has an intrinsic capacity for sensing mechanical stimuli (mechanosensing) and converting these into biochemical events that regulate adaptive protein synthesis. Converting mechanical energy into biological events is termed mechanotransduction. However, the mechanisms underlying the link between mechanosensing, mechanotransduction and the subsequent regulation of protein synthesis and breakdown remain poorly understood. ...
Manipulating Wnk kinase function as a therapeutic application in neurological diseases KU Leuven
Wnk is an essential kinase, found to be misregulated in different diseases such as hypertension, cancers and neuropathies. However, Wnk has only been extensively studied in renal tissue, where it regulates chloride homeostasis, and not much is known of Wnk function in other tissues. We recently discovered that loss of Wnk kinase in Drosophila sensory neurons results in axonal branching defects and axon degeneration. Loss of Wnk in ...