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Novel anatomical and functional biomarkers of lung disease and therapy dynamics in preclinical rodent models KU Leuven

Greetje Vande Velde
Biomedical MRI, Environment and Health
Lung diseases such as fibrosis, asthma, cystic fibrosis, infection and cancer are life-threatening conditions, which slowly deteriorate quality of life and for which our knowledge on etiology and/or effective treatment options still contains important gaps. To unravel disease processes and to test novel therapeutic approaches, investigators typically rely on end-stage procedures such as serum analysis, cyto-/chemokine profiles and selective ...

Neurological biomarkers in predicting upper limb function and treatment effects in children with unilateral cerebral palsy. KU Leuven

Hilde Feys
Research Group for Neurorehabilitation (eNRGy), Translational MRI, Locomotor and Neurological Disorders
Children with unilateral cerebral palsy (CP) face many sensorimotor impairments and limitations in their arm and hand function. In this project, we will use state-of-the art technology including brain imaging and non-invasive brain stimulation to identify which neurological biomarkers best predict upper limb (UL) function in children with unilateral CP. This proposal is triggered by the current inability to provide well-targeted UL treatment ...

Assessment of renal function in dogs with diabets mellitus and dogs with Cushing's disease using new renal biomarkers Ghent University

Sylvie Daminet
Department of Small Animal

Endocrine disorders such as diabetes mellitus and Cushing's disease can cause nephropathies. The aim of this project is to assess the influence of these disorders on renal function in dogs using new renal biomarkers that allow early detection and localisation of renal damage. Furthermore, urinary protein profiling will be used in order to detect supplemental renal biomarkers.

Muscle functional MRI as an innovative biomarker for fiber type composition. Study in healthy control subjects and chronic low back pain patients. Ghent University

Department of Rehabilitation Sciences and Physiotherapie

The invasive character of biopsy restricts extensive research on muscle fiber typing in trunk muscles. A noninvasive, in vivo alternative for biopsy may be found in Magnetic Resonance Imaging (MRI). The objective of this project is to validate T2 relaxation time as an innovative biomarker for fiber type distribution and to gain fundamental insight in structural subdivision in lumbar muscles.



Research into biomarkers for early detection of Autosomal Dominant Polycystic Kidney Disease KU Leuven

Ann Van Schepdael
Pharmaceutical Analysis, Woman and Child

The kidneys, two bean shaped organs located on either side of the spine in the back of the abdomen, are important excretory organs of the human body. Apart from the removal of waste, kidneys have other important functions such as maintaining the blood pressure and the activation of vitamin D. Since these tasks are essential for a healthy life, we can say that a good renal function is vital. Nevertheless, today exist a variety of kidney ...

Turning the understanding of inflammation-related pathology into new biomarkers and treatments using next-generation technologies and high-throughput data mining. University of Antwerp

Benedicte De Winter
Laboratory Experimental Medicine and Pediatrics (LEMP)
The Laboratory of Experimental Medicine and Pediatrics - within the Faculty of Medicine and Health Sciences and closely linked to the Antwerp University Hospital - focusses its research on the study of inflammation in a clinically relevant context built on interdisciplinary methodologies and collaborations. To remain in the forefront of research we perform ground-breaking experimental, as well as clinical and translational research from bench to ...

Identification of Real-World Trunk Biomarkers for Fall Risk Detection KU Leuven

Kurt Claeys
Rehabilitation Sciences, Bruges Campus
Over one-third of people older than 65 years fall each year leading to injuries, hospitalization or fatality. Fall prevention increases quality of life, as well as minimizes the pressure of rising social costs. Identifying risk factors for falls is important for accurate fall risk detection. Guidelines from RIZIV uses clinical scales to assess fall risk, but low sensitivity is reported for these tools. Using trunk motion as a biomarker for fall ...

What causes cognitive decline in chemotherapy treated cancer survivors? An integrative study using multi-model brain imaging, cognitive testing, measurement of stress & inflammatory biomarkers. KU Leuven

Stefan Sunaert
Translational MRI
Cognitive impairment has been recognized as a possible adverse effect of breast cancer and its treatment. The aim of the proposed project is to refine earlier findings of the neural correlates of chemotherapy-induced cognitive impairment using multi-model PET-MRI imaging. This to visualize neuro- inflammation and specify white matter microstructural and functional brain connectivity changes in combination with in-depth neurocognitive testing and ...

Longitudinal in vivo follow-up of PET biomarkers in neurological disease models. University of Antwerp

Stefanie Dedeurwaerdere
Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO), Translational Neurosciences (TNW)
Chronic neurological diseases such as epilepsy and schizophrenia are difficult to manage and severely disabling disorders. Moreover, they are putting a huge burden on our social health care system. Currently, there is no available therapy that effectively halts or retards the development or progression of these conditions. The more we learn, the more it becomes clear that these neurological diseases are extremely complex as they do not have a ...

Micro/nanotechnology and medical diagnostics: Development of a multiplexed nano-bio-sensing system for in-parallel monitoring of multiple health biomarkers Ghent University

Ioulia Tzouvadaki
Department of Electronics and information systems

Multiplexed biosensing technologies can bring an important impact to the medical practice reflecting more accurately the health status and favouring a quicker, more accurate, and early detection of a disease by maximizing the amount of information that can be obtained.

The project aims to develop a new biosensing technology based on micro/nano-systems for performing reliably and efficiently monitoring of multiple key biological ...