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Novel anatomical and functional biomarkers of lung disease and therapeutic effects in preclinical rodent models KU Leuven

Greetje Vande Velde
Biomedical MRI, Environment and Health

Pulmonary fibrosis is the replacement of healthy tissue by an excessive deposition of extracellular matrix components leading to an irreversible destruction of the lung architecture. It is a devastating condition resulting in a decreased lung compliance, disrupted gas exchange and respiratory failure. Currently, there are two therapeutics on the market that slow down the progression of pulmonary fibrosis. Regardless many efforts made in the ...

Unraveling the potential of circular RNAs as novel biomarkers of radiation exposure and- sensitivity and their functional characterization in the radiation response University of Antwerp

Winnok De Vos
Laboratory of cell biology and histology
Biomarkers for radiation exposure are important for a number of reasons. With a growing nuclear threat, the identification of efficient biomarkers for radiation exposure that enable fast triage of exposed individuals is becoming increasingly important. Likewise, the identification of robust biomarkers of radiosensitivity should help tuning current tumor radiotherapies to more personalized schemes. Current golden standard methods for biodosimetry ...

SUBJECT-SPECIFIC GRAPH MEASURES BASED ON RESTING-STATE FUNCTIONAL MRI AS POTENTIAL BIOMARKERS FOR ALZHEIMER’S DISEASE KU Leuven

Patrick Dupont
Laboratory for Cognitive Neurology

The brain is one of the most complex systems. To understand the brain we have to understand how the brain works, in terms of how remote/non-remote brain regions effectively interact and how brain regions are organized to process information. Therefore, it is important to understand the brain as a network. To quantify the performance of brain networks, graph theory is a very suitable method. It has been proposed that graph measures of ...

Functional validation of SNPs in VEGFR-1 and HIF2A as biomarkers for bevacizumab therapy. KU Leuven

Diether Lambrechts
Laboratory of Translational Genetics (VIB-KU Leuven)
One of the most commonly used targeted cancer therapies is bevacizumab or anti-VEGF therapy. About half of the patients respond to this therapy, but biomarkers to predict which patients will respond currently do not exist. A screening of genetic variants (SNPs) identifed a variant in the VEGFR-1 gene as a predictive biomarker for response to anti-VEGF therapy. This coding SNP affects the codon usage for a tyrosine residue in the VEGFR-1 mRNA. ...

Studying brain network changes in epilepsy by combining functional magnetic resonance imaging, intracranial electroencephalography and opto-/chemogenetics to unravel biomarkers for disease prognosis and efficacy of anti-epileptic treatments Ghent University

Christian Vanhove
Department of Electronics and information systems

Epilepsy is a neurological disorder characterized by recurrent epileptic seizures. In about 30% to
40% of the patients with epilepsy, the seizures are not sufficiently controlled with anti-epileptic
drugs (AEDs). Currently, it is still very difficult to predict which patients will respond to AEDs or
deep brain stimulation (DBS), another treatment possibility. Research has shown that abnormal
functional brain networks ...

Novel anatomical and functional biomarkers of lung disease and therapy dynamics in preclinical rodent models KU Leuven

Greetje Vande Velde
Biomedical MRI, Environment and Health
Lung diseases such as fibrosis, asthma, cystic fibrosis, infection and cancer are life-threatening conditions, which slowly deteriorate quality of life and for which our knowledge on etiology and/or effective treatment options still contains important gaps. To unravel disease processes and to test novel therapeutic approaches, investigators typically rely on end-stage procedures such as serum analysis, cyto-/chemokine profiles and selective ...

Catheter-based sensors for the intestinal detection of molecular biomarkers in the context of functional bowel disorders KU Leuven

Patrick Wagner
Soft Matter and Biophysics, Translational Research in GastroIntestinal Disorders, Newcastle University

Food-induced abdominal symptoms are extremely common and remain poorly understood. In a recent Belgian survey, 18% of the adults reported symptoms of the irritable bowel syndrome (IBS), and half of them identified certain foods as triggers of their symptoms. Histamine and serotonin are two important signaling molecules in the gastrointestinal mucosa, thought to be involved in adverse reactions to food. However, it has been notoriously ...

Functional biomarkers of cartilage mechanics in osteoarthritis – an MRI-based, multi-scale adaptive modeling framework to bridge from in vitro destructive testing to in vivo clinical applications KU Leuven

Ilse Jonkers
Human Movement Biomechanics Research Group

Osteoarthritis (OA) is the most common joint disease and significantly impairs the quality of life of those affected by this painful progressive disease. As a consequence, the economic burden is high for both the individual and society. Today, no successful preventive interventions have been identified yet. It is however known that cartilage degeneration and loss of its unique mechanical properties is the hallmark of OA and that mechanical ...

Neurological biomarkers in predicting upper limb function and treatment effects in children with unilateral cerebral palsy. KU Leuven

Hilde Feys
Research Group for Neurorehabilitation (eNRGy), Translational MRI, Locomotor and Neurological Disorders
Children with unilateral cerebral palsy (CP) face many sensorimotor impairments and limitations in their arm and hand function. In this project, we will use state-of-the art technology including brain imaging and non-invasive brain stimulation to identify which neurological biomarkers best predict upper limb (UL) function in children with unilateral CP. This proposal is triggered by the current inability to provide well-targeted UL treatment ...