Disturbed lipid processing skews foamy macrophages to a disease-promoting phenotype in MS Hasselt University
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease of the central nervous system in which microglia and infiltrated macrophages play a crucial role. Driving these phagocytes towards an anti-inflammatory and regenerative phenotype is considered a promising strategy to halt MS disease progression. Myelin-containing foamy phagocytes are the most abundant immune cell subtype in active MS lesions. To date, however, the impact that they ...