Can high-resolution optical projection tomography of the interplay between cryptococci and macrophages unravel the enigmas in pulmonary and cerebral cryptococosis pathogenesis? KU Leuven
Scientific state-of-the-art & aims of this proposal:
Cryptococcus neoformans and C. gattii are encapsulated yeasts that can cause life-threatening disease in both immune-competent and immune-suppressed individuals (e.g. cancer therapy patients or patients with AIDS). Cryptococcosis affects the lung and may spread to the brain, manifesting itself by meningitis or pseudocystic brain lesions. It ...