The Pathophysiology of Cystic Fibrosis Lung Disease KU Leuven
Cystic fibrosis (CF) lung disease is characterized by recurrent cycles of infection and inflammation, leading to airway remodelling. Central to this doctoral thesis was the use of end-stage CF lungs in order to gain further insight into small airway disease and the inflammatory pattern eventually culminating in respiratory failure. Firstly, using high resolution computed tomography (HRCT) and micro-CT, we demonstrated that small airway ...