The link between mitochondrial dysfunction and epigenetic alterations in metabolically compromised oocytes: a key pathway to subfertility and a target to improve embryo quality and offspring health. University of Antwerp
Maternal metabolic disorders, e.g. obesity, affect millions worldwide and are known to cause subfertility. Altered ovarian micro-environment and the direct impact on oocyte quality is a key factor in this pathogenesis. The oocyte undergoes dynamic epigenetic reprogramming during normal follicular development. Timely acquisition of epigenetic modifications is critical for genomic imprinting and regulation of transcription during subsequent ...