Projects
The development of a treatment for feline infectious peritonitis virus (FIPV) Ghent University
summary, the objective of the research mandate is to develop a treatment that allows to overcome a FIPV infection, the immune system of the cat. Therefore will / will: - The accessory proteins that play a role in antibody dependent cell lysis identified - Monoclonal antibodies are generated against the protein blocking antibody dependent cell lysis - The therapeutic antibody clone detectable with the strongest activity - Preliminary in vivo ...
Control of feline enteric coronavirus in Flemish shelters and catteries to prevent feline infectious peritonitis Ghent University
WWith a research project, my lab wants to lay the foundation to realize this combined approach of diagnosis and prevention. This will be done by investigating which variants of the harmless, but causative, felien enterisch coronavirus (FECV) occur in Flanders, which mutations are at the basis of the FIP development, which management measures are most effective to reduce the FECV circulation in shelters and farms, and by which testing ...
FIP-project: Feline infectious peritonitis Ghent University
Feline infeectieuze peritonitis (FIP) is caused by a feline coronavirus (FCoV) and is one of the leading causes of death in cats nurseries and shelters that huge animal, financial and emotional losses entails FCoVs occur in two virulence variants or pathotypes which the pathogenic power is determined by their cell tropism. The feline enteric coronavirus (FECV) has a tropism for intestinal epithelial cells, called enterocytes. FECV present is ...
Upregulation of sialyl lewis X of Feline Infectious Peritonitis, a basis for the development of a diagnostic test Ghent University
Early replication stages of feline enteric coronavirus in its real target cell, the enterocyte. Ghent University
Feline infectious peritonitis (FIP) is the most feared infectious cause of death in cats, caused by the feline infectious peritonitis virus (FIPV). FIPV is a virulent mutant of the feline enteric coronavirus, an ubiquitous but harmless intestinal virus. The mutation provides FIPV with tools to replicate in monocytes, in which it can be spread over the whole body, resulting in a fatal, systemic disorder. As for other coronaviruses, curative ...