Projects
Fatty acid elongation and desaturation in control of lesion progression and repair in multiple sclerosis. Hasselt University
Targetting fatty acid synthesis as a therapy to promote remyelination in MS Hasselt University
Targeting fatty acid synthesis to induce remyelination in MS. Hasselt University
High non-esterified fatty acid concentrations during preimplantation embryo development: Consequences for female fertility and offspring's health. University of Antwerp
High non-esterified fatty acid concentrations during preimplantation embryo development: Consequences for female fertility and offspring's health. University of Antwerp
Effect of plant secondary metabolites on in vitro biohydrogenation of polyunsaturated fatty acids by rumen microbes Ghent University
The large interest in improving the health value of ruminant products has driven research to find ways to manipulate the rumen fatty acid metabolism. Plant secondary metabolites, such as essential oils, flavonoids, tannins and spaonins have received increasing interest as natural alternatives to the use of antibiotics. Screening of different herb metabolites will be performed using a rumen stimulation in vitro technique.
Exploiting a novel link between metabolism and acetylation to predict and to treat metastasis formation KU Leuven
Metastasis formation is the leading cause of death in breast cancer
patients with nearly 30% of patients developing metastases.
Unfortunately, we currently cannot predict which patient will develop
metastases due to our limited understanding of how cancer cells gain
metastatic capacity. This greatly reduces the application of
personalized follow up screening and preventative measures. We
have discovered that ...
The Effects of Gut Bacterial Metabolites Short-Chain Fatty Acids on Stress-Induced Impairment in Core Executive Functions KU Leuven
The gut microbiome has emerged as a likely mediator of physiologic (e.g., hypothalamic-pituitary-adrenal (HPA) axis), emotional, and cognitive responses to stress. The short-chain fatty acids (SCFAs) acetate, propionate and butyrate are the main metabolites of fermentation of complex carbohydrates in the colon by the gut microbiota, and are thought to play a key role in microbiota-gut-brain communication. The effects of SCFAs on these ...
Interplay between short-chain fatty acids and the circadian clock in the rhythmicity of contractility and hormone release in the gut KU Leuven
Our bodies keep track of time using circadian clocks to anticipate predictable 24-h environmental changes. The circadian system and the timing of food intake dictate diurnal rhythms in the microbiota. In turn, microbial metabolites such as short-chain fatty acids (SCFAs) can entrain the circadian system. The aim of this PhD thesis was to identify the role of the circadian clock in the diurnal rhythms of SCFA concentrations and their effects ...