Fatty acid metabolism as a novel adaptive response to high intratumoral pressure/temperature and promising target for the treatment of solid tumors KU Leuven
We put forward the innovative and unconventional concept that changes in fatty acid elongation and desaturation (at least in part) function as an adaptive response to the high intratumoral pressure and temperature that is a hallmark of solid tumors. Here, based on a body of preliminary evidence we aim to consolidate this novel concept and to explore its potential as an exploitable and universal target for the treatment of solid tumors.
Endothelial cells (ECs) line blood vessels to supply oxygen and nutrients to tissues. Abnormal blood vessel growth (angiogenesis) promotes cancer growth and spread. Current strategies to inhibit angiogenesis rely on the inhibition of the growth factor VEGF. However, the efficacy of this treatment is limited by intrinsic refractoriness and acquired drug resistance. Since ECs need increased amounts of energy and must maintain redox homeostasis ...
Fatty acid metabolism as a key mediator of therapy resistance in BRAF-mutant malignant melanoma. KU Leuven
This project will explore the potential of a new strategy to treat Hepatocellular carcinoma (HCC). This strategy involves the combination of cyclotoxic agents, which are currently applied in the clinic but in monotherapy insufficient to provice longlasting remission, with agents targeting the adaptive mechanisms of a recently identified tumour cell subpopulation presumably responsible for chemoresistance and relapse.
The effect of rewiring fatty acid metabolism on the epigenetic landscape of metastasizing breast cancer cells. KU Leuven
This project will invesigate how pyruvate metabolically regulates CP4H metastatic growth. I will address this objectives by studying proline metabolism and its inhibition in 3D cultured breast cancer cells and in a metastatic breast cancer mouse model using metabolmics, imaging and molecular biology techniques.