Tumor necrosis factor Receptor-Associated Factors in signal transduction and susceptibility to infection. KU Leuven
Primary immuno-deficiencies constitute a heterogeneous group of disorders resulting in an underdeveloped and/or functionally compromised immune system, predisposing children and adults to infections. We hypothesize that there are other yet unidentified immune defects. In the current research proposal, we will study “Tumor necrosis factor receptor (TN F-R)-Associated Factors” (TRAFs) as genes that can confer susceptibility to infection. TRAFs ...