Projects
Clinical, Immunological and Functional Study of ADA2 deficiency KU Leuven
ADA2 deficiency is a devastating rare inherited disorder caused by biallelic deleterious mutations in the ADA2 gene. Clinical manifestations include vasculopathy ranging from cutaneous vasculopathy (livedo) to lacunar brain infarction. Moreover, patients can have bone marrow failure and immunodeficiency. While anti-TNF agents are usually effective in controlling vasculopathy, bone marrow failure and immunodeficiency are often refractory. In ...
Perturbations in nucleotide biosynthesis inhibits Salmonella biofilm formation KU Leuven
The overall goal of this project was to investigate the molecular link between nucleotide metabolism and biofilm formation, with a particular focus on pyrimidine starvation. The potential of using nucleoside based drugs as antibacterial compounds was also explored.
In order to determine which intermediates in the de novo pyrimidine biosynthesis pathways are required for biofilm formation, a set of single gene knockout mutants ...