MEANS AND METHODS TO TREAT INFLAMMATORY DISEASES Flanders Institute for Biotechnology
The present application relates to the field of inflammatory diseases, particularly to inflammatory diseases characterized by an M1 macrophage response, even more particularly to sepsis and to Trypanosoma infection. It is disclosed that loss of miR210 expression reduces the severity of symptoms associated with sepsis and Trypanosoma brucei infection. The invention provides substances modulating miR210 expression and/or activity, in particular RNA molecules inhibiting miR210 expression and/or activity and medical uses of these miR210 inhibitors. Methods are disclosed to screen for medicaments ...