INSITE - A new combined experimental and theoretical framework for studying liquid protein condensates and its application to discover new targets for misfolded protein diseases KU Leuven
Membrane-less organelles (MLOs) are Nature’s way of exploiting physical phase transitions to locally concentrate biomolecules in cells without using lipid envelopes. MLOs have a plethora of natural functions, but conversely also have a critical relation with misfolded protein diseases. Indeed, the components of MLOs are intrinsically disordered proteins (IDPs), and many of these have the capacity to pathologically aggregate inside MLOs ...