Projects
INSITE - A new combined experimental and theoretical framework for studying liquid protein condensates and its application to discover new targets for misfolded protein diseases KU Leuven
Membrane-less organelles (MLOs) are Nature’s way of exploiting physical phase transitions to locally concentrate biomolecules in cells without using lipid envelopes. MLOs have a plethora of natural functions, but conversely also have a critical relation with misfolded protein diseases. Indeed, the components of MLOs are intrinsically disordered proteins (IDPs), and many of these have the capacity to pathologically aggregate inside MLOs ...
A new framework for Experimental Design in Earth Sciences using Bayesian Evidential Learning (BEL4ED) Ghent University
Earth Sciences predictions are facing large uncertainty related to the complexity and the lack of knowledge of the subsurface. Acquiring the most informative data set to reduce uncertainty is therefore highly valuable. However, its identification rapidly becomes intractable for large scale
problems. We propose to stochastically solve this problem under large uncertainty using our newly developed Bayesian Evidential Learning ...
Combined experimental and computational analysis of morphogenic processes in the physical framework of the (un)jamming transition KU Leuven
Morphogenic processes during embryonic development are characterised by phenotypical changes that can be interpreted from a physical perspective as phase transitions emerging from interactions between a large number of cells. In particular, the jamming phase transition – a transition form a fluid-like to a solid-like state – was found to control zebrafish anteroposterior (AP) axis elongation. However, the regulation of the jamming transition ...
INSITE - A new combined experimental and theoretical framework for studying liquid protein condensates and its application to discover new targets for misfolded protein diseases Hasselt University
Could You Repeat That, Please? Increasing The Quality And Replicability Of Physiological Virtual Reality Research Through A Comprehensive Experimental Framework Ghent University
Virtual reality (VR) experiments are increasingly employed because of their internal and external validity compared to real-world observation and laboratory experiments. Recently, the attention of human behavioural research in VR has focused on the use of psychophysiological signals, such as electroencephalography (EEG) or electrocardiography (ECG). However, the replicability of these research findings is hardly existent due to inconsistent ...
Theoretical and experimental study of membrane action in orthotropic concrete slabs in the framework of robustness assessments of concrete structures Ghent University
When a concrete slab is excessively loaded, membrane forces can considerably increase their load-carrying capacity and thus the robustness of concrete structures. The research aims at the study of tensile membrane action on the basis of large-scale tests. Analytical and numerical models are developed and assessed against experimental results. Based on these investigations, design guidelines are suggested.
Combined experimental and computational study of electronically modulated metal-organic Frameworks (MOF) catalysts Ghent University
Support Well-being, Public Health and Family - EF55: Analysis of experiments and numerical simulations of fire tests for the development of an assessment framework for fire safety in elderly homes Ghent University
In this project fire tests and numerical simulations thereof (CFD: Computational Fluid Dynamics) are analysed. Additional CFD simulations are performed, of scenarios that are not tested experimentally. Based on the results of the analysis an assessment framework is elaborated, expressing the fire safety level as function of fire protection measures, in the context of elderly homes. This assessment framework is useful for Flemish regulations ...