Projects
Effects of functional strength training and neuromuscular electrical stimulation during hospitalisation for acute exacerbation of chronic obstructive pulmonary disease: a randomised controlled trial Hasselt University
Innate imprinting of resident alveolar macrophages by allergic airway inflammation: mechanism and consequences for asthma exacerbation Ghent University
In a mouse model of asthma, resident alveolar macrophages showed an increased inflammatory reactivity upon post-infection of the asthmatic lung. This project aims to elucidate the mechanism underlying the altered macrophage innate functionality and hereby to enable interference with asthma exacerbation.
Elucidating the clinical and genetic determinants of exacerbations of Chronic Obstructive Pulmonary Disease (COPD) in the elderly Ghent University
Chronic Obstructive Pulmonary Disease (COPD) occurs frequently in elderly people, and is associated with episodes of worsening symptoms such as dyspnea, coughing and sputum (i.e. exacerbations). These COPD exacerbations sometimes require hospitalisation and increase the risk of mortality. We will perform epidemiologic research in large population-based cohort studies to unravel the clinical and genetic risk factors of COPD exacerbations.
Machine Learning-based solutions for the prediction of acute COPD exacerbations Ghent University
Rational antibiotic use in COPD exacerbations Ghent University
The disease severity and socio-economic impact of COPD is determined by acute exacerbations. More than 70% of COPD patients with acute exacerbations in primary care are treated with antibiotics, although the causal role of bacteria is often uncertain and evidence for use limited. Through population research, we want to optimize and personalize the risk-benefit ratio of antibiotic treatment in COPD.