The role of intestinal microbiota in the development of inflammatory bowel diseases: identification of potential beneficial and harmful microbiota through ex vivo organoid technology. KU Leuven
The exact pathogenesis of inflammatory bowel diseases (IBD) remains incompletely understood, but a loss of tolerance to gut microbiota seems crucial. The differentiation of intestinal stem cells (ISC) into progeny cells is suggested to be disturbed in IBD, but the exact impact of microbiota on ISC is unknown. We hypothesize that ISC behave differently upon stimulation with luminal microbiota leading to altered differentiation into progeny, ...