Understanding embryonic chromosome instability and the origins of structural genetic variation by genome sequencing of single blastomeres. KU Leuven
Although a cell produces an assortment of products that protect, inspect and if necessary heal its valuable genetic code, DNA-mutations can accumulate during a cell’s life cycle. This is exemplified by the acquisition of somatic genetic lesions that cause cancer, but also by the birth of disabled children due to a genomic aberration acquired during gametogenesis or early embryogenesis. In fact, most likely we all are genetic mosaics early on ...