Prospective longitudinal MRI and PET studies of epileptogenesis and brain plasticity in epilepsy using [18F]fluorodeoxyglucose (FDG), [18F]flumazenil (FMZ), [18F]MK-9470 in small animals with epilepsy. KU Leuven
Nodding Syndrome: a trans-disciplinary approach to identify the cause and decrease the incidence of river epilepsy (NSETHIO). University of Antwerp
Alzheimer’s disease (AD) is the most common neurodegenerative disease causing dementia and one of the leading causes of death. Currently, there is no curative therapy for AD. Epilepsy and sleep-wake disturbances are common co-morbid conditions in AD which are often present in an early stage of the disease. They not only cause more rapid deterioration of the disease by impairing memory and behaviour, but are also an increasing burden on the ...
Multimodal profiling of people with epilepsy to determine which signals are clinically useful for long-term home monitoring KU Leuven
Epilepsy is a serious and common neurological disorder marked by recurrent epileptic seizures, caused by abnormal, excessive and synchronous electrical discharges in the brain. It has a prevalence of around 0.5% and affects nearly 50 million people worldwide. As many as 30% of patients with epilepsy are refractory, which means that epilepsy is not controlled with two or more well used anti-epileptic drugs. In order to develop and evaluate new ...
Studying brain network changes in epilepsy by combining functional magnetic resonance imaging, intracranial electroencephalography and opto-/chemogenetics to unravel biomarkers for disease prognosis and efficacy of anti-epileptic treatments Ghent University
Epilepsy is a neurological disorder characterized by recurrent epileptic seizures. In about 30% to
40% of the patients with epilepsy, the seizures are not sufficiently controlled with anti-epileptic
drugs (AEDs). Currently, it is still very difficult to predict which patients will respond to AEDs or
deep brain stimulation (DBS), another treatment possibility. Research has shown that abnormal
functional brain networks ...
New approaches for detection and modulation of abnormal brain networks in a preclinical model for epilepsy based on a combination of functional magnetic resonance imaging, optogenetics, chemogenetics and intracranial electroencephalography Ghent University
Epilepsy is a common neurological disorder that is characterized by the occurrence of spontaneous
seizures. Unfortunately, about one third of the patients still have seizures despite treatment with
anti-epileptic drugs (AED). In addition, many patients have severe side effects due the large doses
of AED they need to take. Other treatments are required to improve the quality of life of those
patients. In order to find ...
Multimodal monitoring of electrophysiological signals in childhood epilepsy and neonatal encephalopathy KU Leuven
EEG records electrical activity in the brain generated by pyramidal cells forming large neuronal networks. EEG monitoring provides a constant assessment of brain function and has 3 major applications in neurological practice. It can be used to appreciate epileptic activity in patients with ...