The role of the p53 tumour suppressor protein in epigenetic maintenance of genomic integrity via transcriptional silencing and stabilisation of heterochromatic domains. Ghent University
p53 is the most frequently inactivated protein in human cancers. It works as a transcription factor responsible for the majority of stress-responses which protect cells from transformation. Despite thorough studies, the p53 pathway is not fully elucidated. This project investigates p53-mediated and histone-methyl-transferase-dependent epigenetic silencing of genes and stabilisation of chromosomal heterochromatin domains, and will hopefully ...