Projects
Chemopreventive or breast cancer promoting? A comparative transcriptomic, epigenetic and metabonomic study of isoflavones, tamoxifen and raloxifene in healthy breast tissue. Ghent University
Upon soy consumption, isoflavones reach exposure levels in human breast tissue at which ERβ agonistic, putative protective, effects may occur. Yet, the clinical implications of these findings require further investigation. This project aims to characterize the differential activation of estrogen-responsive genes between dietary isoflavones and chemopreventive therapeutics in women undergoing breast reduction surgery by a controlled dietary ...
Characterisation of epigenetic control of cancer-inflammation by jumonji histone demethylases during hypoxia University of Antwerp
The consequences of high free fatty acid concentrations in the micro-environment of the oocyte and zygote on metabolic, genetic and epigenetic quality parameters of the pre-implantation embryo. University of Antwerp
Functional relevance of epigenetic changes in mental retardation. KU Leuven
The high- throughput identification and validation of epigenetic biomarkers for cardiovascular disease. Ghent University
In the Western World, cardiovascular diseases (CVD) represent the most important cause of death. The interaction between aging, genetics and lifestyle in the development of CVD pints towards an epigenetic component. Therefore, a high- throughput epigenetic profiling of CVD will be performed, based on samples from the longitudinal Asklepios study. This may deepen the understanding of the molecular pathology of CVD
Separation, identity and intimacy during adolescence and emerging adulthood: Prospective testing of epigenetic hypotheses Ghent University
Separation-individuation theory (Blos, 1967) and EriksonU+2019s (1968) lifespan developmental theory claim that the developmental tasks of separation, identity and intimacy follow each other in a sequential order during adolescence and emerging adulthood. Using new conceptualizations and longitudinal research with adolescents aged 15 to 22 years, this research project prospectively tests the central hypotheses (phasing and conditionality) of ...