The role of the SOX11 lineage-dependency factor as epigenetic master regulator in neuroblastoma Ghent University
We recently identified SOX11 as an important adrenergic lineage-specific transcription factor in neuroblastoma (NB). Through the induction of factors involved in chromatin landscaping, SOX11 has an epigenetic mediator role in controlling the sympathoblast enhancer landscape.To gain insights into SOX11 dependency, we aim to understand how the normal role of SOX11 during sympathoblast differentiation is co-opted during the process of malignant ...