Projects
Computational design targeting the androgen receptor, CCR8 receptor, and NSP15 enzyme KU Leuven
We successfully employed computational methods to discover a new AR-targeted therapy for the treatment of prostate cancer. Prostate cancer is the second most common cancer and affects millions of men each year worldwide. Targeting AR LBD dimerization could discover novel inhibitors that might overcome resistance mechanisms that occur in the current therapy.
Here, we successfully developed the first-generation AR LBD dimerization ...
TNF-alpha converting enzyme (TACE) is a major survival factor after CNS trauma Hasselt University
The effect of Mycoplasma enzymes on the antiviral and anticancer activity of nucleoside analogues KU Leuven
TALENT: Engineering human tyrosine ammonia lyase (TAL) enzymes to treat inborn errors of tyrosine metabolism Vrije Universiteit Brussel
DNA methylation dynamics underlying therapy resistance in cancer KU Leuven
Plentiful DNA methylation changes have been associated with the cellular response to anti-cancer therapeutic pressure. However, it has not systematically been assessed how these changes arise, whether and how they causally contribute to therapeutic resistance and what their impact in the clinic is. In this study, we therefore investigate if and how DNA methylation patterns can underlie the cellular expression and phenotype changes that allow ...
Fight against Mycobacterium tuberculosis infection with cell wall enzymes Ghent University
IWT / SB-2014 batch of IWT /
IWT/ SB / van Schie Loes / 131545 Fight against Mycobacterium tuberculosis infection with cell wall enzymes
Background The major global health threat tuberculosis is caused by Mycobacterium tuberculosis (Mtb). Mtb has a complex cell envelope U+2013 a partially covalently linked ...
Regulation of the protein phosphatase scaffold RepoMan during the cell cycle KU Leuven
Protein kinases and phosphatases are antagonistically acting enzymes that cooperate to control the speed, amplitude and specificity of phosphorylation signals in numerous cellular processes, including mitosis. Early mitotic events are characterized by bulk phosphorylation of specific proteins by kinases such as CDK1/Cyclin B and Aurora B. The mitotic exit depends on protein phosphatases, mainly PP1 and PP2A, which remove phosphate groups from ...
Transplacental passage of paracetamol and its metabolites KU Leuven
It is estimated that over 90% of pregnant women take over-the-counter or prescription medication. Nevertheless data on transplacental transfer or fetal effects of prenatal drug exposure are lacking, even for the most frequently administered drugs during pregnancy like paracetamol (PCM).
PCM is one of the most commonly used over-the-counter medicines and is considered the safest painkiller for pregnant women. In Europe, 50-60% of ...