Contribution of serine synthesis enzyme PSPH in the pathogenesis and therapeutic resistance of T-ALL KU Leuven
Cancer cells rewire their energy metabolism during tumorigenesis. My host lab recently showed that the majority of T-cell acute lymphoblastic leukemia (T-ALL) samples overexpress serine/glycine synthesis enzymes and that these leukemic cells depend on this pathway for cancer progression. Whereas non-malignant cells typically take up serine and glycine from their environment and will not synthesize it themselves, some cancer cells activate ...