Projects
Ephrins and their receptors are crucial for the recruitment of pathogenic TH17 cells to the central nervous system in multiple sclerosis patients Hasselt University
MicroRNA regulation of enteric glia phenotype and function Hasselt University
Modulation of resident macrophages by enteric neurons in the muscularis externa KU Leuven
The gastrointestinal tract represents the largest interface between the environment and the organism. It is essential for digestion and absorption of nutrients, however at the same time acting as a barrier against potentially noxious ingested elements and infectious agents. Activation of a potent and specific immune response against pathogens counteracts and prevent invasion of harmful microorganisms. However, a tight control of this ...
Role of glial cells in the assembly and function of enteric neuron circuitry. KU Leuven
The role of glial cells in enteric neurotransmission. KU Leuven
Characterisation of enteric neurons during the development of the zebrafish, Danio rerio. University of Antwerp
Uncovering Enteric glia-macrophage communication in the intestinal homeostasis and inflammation. KU Leuven
One of the main tasks of the immune system is to appropriately react to “danger” or “non-danger” signals. This is even more relevant in the intestine, where immune cells are constantly presented with foreign substances as food. Hence, the balance between immune activation versus tolerance should be tightly regulated to maintain intestinal homoeostasis and to prevent indiscriminate immune activation against the gut content. Loss of this ...
Coordination of intrinsic neural network connectivity in the gut by enteric glial DISC1 Hasselt University
Neuron-associated macrophages in the gut as novel target for the treatment of enteric neuropathies KU Leuven
The gastrointestinal tract has the vital task to digest and absorb ingested food, a complex process requiring
coordinated integration of motility, secretion, vascularization and absorption. Thereto the gastrointestinal tract
is equipped with its own nervous system, the enteric nervous system (ENS), capable of controlling gut function
independently of input from brain or spinal cord. Reduction in number or dysfunction of the ...