Single cell analysis of tumor endothelial cell genomic and transcriptomic heterogeneity KU Leuven
Tumor angiogenesis promotes tumor growth, but current anti-angiogenic treatments lack efficacy and suffer resistance, a formidable unmet medical problem with great societal impact. I hypothesize that the limited success of traditional anti-angiogenics relates to the fact that the angiogenesis field has used the wrong endothelial cell (EC) type for therapy development, i.e. normal ECs (NECs) instead of tumor ECs (TECs), which show genomic ...