Endothelial cell metabolism blockade to induce tumor vessel normalization and improve immunotherapy KU Leuven
Traditional anti-angiogenesis strategies attempt to prune tumor vessels. However, their success is restricted by toxicity and resistance. There is thus an unmet need for new anti-angiogenic strategies with fundamentally distinct mechanisms. An alternative therapeutic paradigm is tumor vessel normalization (TVN). By healing disorganized vessels, TVN improves perfusion and oxygenation, tightens the leaky vascular wall, thus reducing metastasis ...