Stem Cell and Developmental Biology KU Leuven
research
1. Pluripotent Stem Cells and Reprogramming
2. Pluripotent Stem Cell Differentiation
3. Adult Stem Cells
4. Disease Modelling and Regenerative Therapies
research
1. Pluripotent Stem Cells and Reprogramming
2. Pluripotent Stem Cell Differentiation
3. Adult Stem Cells
4. Disease Modelling and Regenerative Therapies
Our team wants to find ways to generate new insulin-producing, glucose-regulated "beta" cells that can be used for transplantation in diabetes patients and ways to regenerate beta cells in the pancreas. We study rodent experimental models as well as human cells. The first aim is based on tissue engineering starting from: 1. Exocrine pancreatic cells: reprogramming of adult exocrine cells to endocrine cells, or transdifferentiation in culture. ...
The laboratory for Cell Genetics (Cytogenetics) studies variation in genotype and phenotype, cell division pathways, cell death and genetic changes relevant for the increase of cancer in human. Genotoxicity tests assess the induction of DNA damage, gene mutations, structural and numerical chromosome aberrations. Their predictivity for cancer induction is supported by international studies relating mutations and activation of cancer related ...
The Research Department of Embryology and Genetics (EMGE) is linked to the Centres for Medical Genetics and Reproductive Medicine and the Department of Paediatrics of the UZ Brussel and consists of several research clusters. Historically, the group has been interested in metabolic diseases such as lysosomal storage diseases and this has led to the close collaboration with the neuro-paediatricians of the hospital, investigating mitochondrial ...
Our research team studies spermatogenesis with a special focus on spermatogonial stem cells. Our current aim is to develop strategies in order to prevent infertility after gonadotoxic treatments. Fertility can be preserved by either limiting the loss of gametes and their precursors or by storing gametes and/or their precursors. Gonadotoxicity is an important side effect of cancer treatments. While adult men can bank their spermatozoa prior to ...
The core business of REGE is the interphase between reproduction and genetics, a wide discipline covering several subdisciplines. Male infertility and the search for genes involved in spermatogenensis is a first topic that is mainly investigated within the Centre for Medical Genetics. A second important topic covers the (epi)genetics of embryos and embryonic stem cells, amongst others the investigation of chromosomal abnormalities, epigenetic ...
Our unit develops knowledge, methods and strategies for early diagnonis, prevention and treatment of diabetes. This objective is addressed through projects that integrate basic research, preclinical development and clinical trials, and benefit from a multidisciplinary expertise in the fields of cell biology and pathology, animal models of disease and therapy, clinical biology and diabetology. A Functional Cytomics Core BioBank stores human ...
The research program of the Laboratory for Molecular Cancer Biology is devoted to the analysis of pathways governing the genesis, progression and maintenance of cancer.Our current research efforts follow from our recent studies on the p53 tumor suppressor. p53 is a transcription factor that functions as a central component of most cellular stress responses. The outcome of p53-mediated surveillance is closely dependent on the type of stress ...
Our research interest is in the epigenetic causes of human diseases. We tackle scientific problems by leveraging cutting edge genomic tools, in vitro and in vivo experiments and insights derived from patient samples. This enables us to address questions that were hitherto impossible to be answered. we am thus uniquely poised to characterize the nature of epigenetic signals that are changed in disease, how they are perturbed and how they ...