The duodenal microbiome in health and disease: composition and dynamics in relation to the bile salt pool, mucosal physiology and therapy in functional and inflammatory disorders of the duodenum. KU Leuven
Translational Research in GastroIntestinal Disorders, Laboratory of Molecular Bacteriology (Rega Institute)
FD is a common disorder with unknown pathophysiology, hampering a conclusive diagnosis and development of effective drugs. In this PhD-project, we studied duodenal and systemic factors in FD. We focused on the duodenal lumen and mucosa, as luminal changes have been proposed to initiate or maintain mucosal alterations. We also separated the duodenal luminal and mucosa-associated microbiota composition. Effects of first-line therapy or PPI were ...