Translational Platform for MSA: Elucidation of Disease-mechanisms and Drug discovery KU Leuven
Objectives:
(i) Generation of MSA-specific iPSC from MSA fibroblasts collected at FCRB and then differentiated into oligodendrocytes (OD).
(ii) Examination of changes in fibroblasts and iPSC-OD of MSA patients versus controls at the transcriptomic, epigenomic and proteomic levels.
(iii) To study the uptake and seeding propensity of structurally distinct α-syn fibrillar forms (amplified from MSA brain) in MSA-derived iPSC-OD. ...