Projects
Validation of autophagy induction as a therapeutic strategy: from drug discovery and preclinical evaluation to safety investigation and biomarker research. University of Antwerp
Target validation and drug discovery towards a therapy for the Rett Syndrome. KU Leuven
Rett syndrome (RTT) (OMIM 312750) is a progressive neurodevelopmental disorder that predominantly affects girls and is caused by loss-of function mutations in the methyl-CpG-binding protein 2 (MeCP2). To date only symptomatic treatment is available. In this project we will validate on the one hand the direct interaction between the transcriptional co-activator lens epithelium-derived growth factor p75 (LEDGF/p75) and MeCP2 as a putative ...
Integrated platform for target identification, validation and drug discovery with applications for neurodegenerative diseases (Neuro-TARGET). University of Antwerp
Improving treatment strategies for different depressive disorders by discovery of novel drug target candidates and discriminatory diagnostic biomarkers. University of Antwerp
Organoid technologies for disease modeling, drug discovery and development for rare diseases KU Leuven
The vast majority of rare diseases are characterized by genetic origin, often severe in pathology and with limited or no treatment options. This also includes the paediatric disorders cystic fibrosis (CF) and cystinosis. Both diseases usually manifest in the first year of life. In recent year, great progress has been made in CF research allowing a swift transfer of novel drugs from bench to bedside. This is fueled by the application of ...
Dissecting host-microbe communication for the discovery of novel bioactive drug leads and agrochemicals. KU Leuven
Microorganisms are prolific producers of chemically diverse natural products with industrially-important biological activities. Microorganisms therefore continue to be a valuable and promising source of novel drug leads and agrochemicals. Plants are home to trillions of bacteria, many of which live in harmony with their host and play a major role in their health. Traditionally, only a few species of soil bacteria have been extensively studied ...
Extending the Amalus drug discovery program: validation studies for immuno-oncological and fibrosis indications to increase the IP and investment value Ghent University
In the Amalus drug discovery program (StepStone), we pursue the establishment of a spin-off company to progress cell-selective inhibitors to clinical trials. This ConcepTT project will increase the IP and investment value of the program.
Our inhibitors possess unique features with respect to competition and represent a first-in-class opportunity.
As single agents, our molecules inhibit metastasis in vivo. In the StepStone ...
Advanced machine learning for Innovative Drug Discovery KU Leuven
The dramatic increase in using of Artificial Intelligence (AI) and machine learning methods in different fields of science becomes an essential asset in the development of the chemical industry, including pharmaceutical, agro biotech, and other chemical companies. However, the application of AI in these fields is not straightforward and requires excellent knowledge of chemistry. Thus, there is a strong need to train and prepare a new ...