Projects
HIV nuclear import and chromatin reading as novel drug targets KU Leuven
The replication cycle of HIV is a complicated interplay between viral and cellular proteins. Until now antiretroviral therapy mainly targets the viral proteins although the interaction between the viral and cellular proteins could be interesting new drug targets. This strategy is mainly of interest because cellular proteins are much less prone to mutations which gives the virus less opportunity to develop drug resistance. My laboratory has ...
Elucidation of drug leads present in the venom of the scorpion Mesobuthus eupeus for the treatment of neuropathic pain. KU Leuven
Exploring physiological factors affecting drug and formulation behavior in the human gastrointestinal tract KU Leuven
Intraluminal profiling is a successful technique which allows you to measure drug concentrations in the gastrointestinal (GI) tract as a function of time by aspiration of fluids in the stomach and upper small intestine (i.e. duodenum). As many of these studies helped us to clarify the behavior of certain oral dosage forms, it was not always straightforward to correlate the gastrointestinal behavior of the drug with concentrations appearing in ...
Exploring UCST behaviour for the design of degradable polymeric drug nanocarriers Ghent University
Cancer is still a leading cause of dead and the use of chemotherapy is prone to severe systemic side effects. By consequence, there is a clear need for more efficient strategies for the delivery of anti-cancer drugs that result in low exposure to healthy cells and tissues but improved delivery of the drug to cancer cells. In view of this, the main objective of this project is to devise a fully synthetic supramolecular approach that allows for ...
Intraperitoneal Drug Delivery for Peritoneal Carcinomatosis: from Bench to Bedside Ghent University
The aim of this project is to contribute to the insights in the physiology of intraperitoneal drug delivery and to develop improved treatment methods for peritoneal carcinomatosis.
Intraperitoneal Drug Delivery for Peritoneal Carcinomatosis: from Bench to Bedside Ghent University
The aim of this project is to contribute to the insights in the physiology of intraperitoneal drug delivery and to develop improved treatment methods for peritoneal carcinomatosis.
Towards innovative approaches for post-mortem drug testing: development of a -drug-screening procedure in nails University of Antwerp
Live cell imaging of phosphatidylserine-annexin A5-mediated pinocytosis: study of targeted drug delivery for cervical cancer University of Antwerp
Intraperitoneal Drug Delivery for Peritoneal Carcinomatosis: from Bench to Bedside Ghent University
The aim of this project is to contribute to the insights in the physiology of intraperitoneal drug delivery and to develop improved treatment methods for peritoneal carcinomatosis.