Projects
FWO-SB-Beurs: Unraveling the structure, function and molecular mechanisms of TBCID24, a new target for drug development against epilepsy and related disorders Vrije Universiteit Brussel
An ontogenic pig model as human pediatric surrogate for preclinical pharmacokinetic and pharmacodynamic drug testing. Ghent University
Drug study designs adapted to the pediatric population are lacking up until now. The primary reason is the absence of representative preclinical methods and animal models that accurately reflect the age-based changes observed in infants. Because of the striking similarities in anatomy and physiology between humans and pigs, the suitability of pigs as a pediatric animal model will be evaluated.
Drug development based on Thymidylate Synthase (TS). KU Leuven
Impact of the dynamic nature of the human gastrointestinal tract on drug and formulation behavior. KU Leuven
Authorized drugs intended for oral administration often suffer from suboptimal or variable performance in clinical practice. In addition, many promising drug candidates fail during costly and time-consuming clinical trials. An important cause of these problems is a poor prediction of intestinal drug absorption. While the pharmaceutical industry expresses an urgent need for more predictive simulation tools, their development requires a ...
Polyoxazolines: A new class of polymers for the fabrication of optimised drug release controlling membranes? KU Leuven
When a drug is taken orally, it needs to first dissolve in the gastrointestinal tract for it to then be absorbed into the bloodstream and exert a therapeutic effect. Extended- or controlled release drug formulations employ different strategies to modulate dissolution and thus absorption and therefore ensure an appropriate therapeutic effect. One such formulation strategy is the use of a rate controlling membrane that modifies the drug release ...
Polymeric Engineering of Anticancer Prodrug Nanocrystals and Intracellular Drug Dynamics Investigation KU Leuven
Despite the high toxicitity and the lack of specificity of the drug administered, chemotherapy remains one of the most clinically used cancer treatments. Cancer research have dedicated a lot of attention to the development of efficient and targeted drug delivery systems (DDSs). However, the success is limited by the cytotoxicity of the complex system used and the poor knowledge on the intracellular dynamics of the drug. With this project, we ...
Development of biomimetic responsive nanocarriers for inhalable drug delivery in lung cancer Hasselt University
DNA methyltransferase 3B (DNMT3B) in multiple myeloma: a pivotal role in myeloma cell survival, drug resistance and disease progression? Vrije Universiteit Brussel
This urges researchers to discover new targets to counter this DR. Next to genetic defects, it is now widely recognized that ...