Projects
Mycobacterium tuberculosis in a cholesterol and fatty acid rich environment: global response to dormancy and antibiotic resistance Ghent University
Little is still known on the role of lipids in the survival of Mycobacterium tuberculosis. The general objective of this research project is to determine and analyze the global genetic expression of M. tuberculosis and to evaluate its drug susceptibility in an in vitro latency model in the presence of lipids cholesterol and fatty acids.
Understanding the role of the WNT signaling pathway in breast cancer dormancy, therapy resistance and cancer relapse. KU Leuven
Breast cancer is the most common and most deadly neoplastic disease among women worldwide. Triple-negative breast cancer is a subtype of breast cancer characterized by the lack of expression of hormone and growth factor receptors, highly aggressive clinical features, poor prognosis, and high relapse rates. The lack of hormone and growth factor receptors renders targeted therapies that are highly efficient in other breast cancer subtypes ...
Eco-evolutionary analysis of persistence in P. aeruginosa KU Leuven
Pseudomonas aeruginosa is an opportunistic human pathogen that is able to cause serious complications in patients with an impaired immune system or in some chronic infections, e.g. in cystic fibrosis patients (CF). In fact, P. aeruginosa is recognized as the most abundant bacterium in pulmonary infections of CF patients. Successfully treating chronic P. aeruginosa infections, however, can be hard due to the ...
The development of transgene Daphnia in a molecular reconstruction of a host-parasite coevolution. KU Leuven
Bioinformatics: from nucleotids to networks (N2N) Ghent University
The platform From Nucleotides to Networks (N2N) aims at setting up pipelines for the processing of the increasing flow of molecular data and the development of techniques for the integration of this data into further bio-informatics research.