Disentangling the complexity and diversity of glucocorticoid receptor signaling Ghent University
Synthetic glucocorticoids (GCs) are frequently used to treat various inflammatory and immune disorders. Unfortunately, long-term GC treatment is associated with many side effects. GCs bind to the glucocorticoid receptor (GR), an intracellular steroid receptor. Identifying improved GR ligands depends has been met with little success so far. Commonly used bio-assays do not fully capture the complex biology of how different GC ligands transmit ...