Projects
Infectious disease models: wildlife ecology, ecological disturbance and transmission to humans. University of Antwerp
Advancing the way uncertainty is accounted for in health economic evaluations based on dynamic infectious disease transmission models. University of Antwerp
Study of intercellular transmission and neurotoxicity of alfa-synuclein in an animal model for Parkinson's disease using optogenetic neuromodulation KU Leuven
Parkinson’s disease, dementia with Lewy Bodies and multiple system atrophy are age-related and devastating neurodegenerative disorders that are characterized by the presence of large proteinaceous clumps of the ɑ-synuclein protein scattered throughout the patient’s central nervous system. The identification of ɑ-synuclein in Lewy bodies made it clear that this protein has a central role in the etiopathogenesis of several age-related ...
Clinical and molecular characterization of a novel congenital disease; the role of PREPL in regulated secretion and neuromuscular transmission KU Leuven
PREPL (PRolyl EndoPeptidase-Like) is deleted in a recessive metabolic disorder characterized by muscle weakness and growth hormone deficiency. Based on the homology with PREP (PRolyl EndoPeptidase) PREPL was predicted to encode an oligopeptidase. Although activity of the catalytic machinery has been demonstrated, no peptide substrates have been identified so far. Recently, we have achieved a breakthrough in determining the physiological ...
Improved understanding of ongoing transmission of leprosy in the Comoros, a region hyperendemic for the disease Institute of Tropical Medicine
TRAIL TRojan snAILs: the role of gastropod snails in disease transmission revealed by state-of-the-art molecular techniques Ghent University
Master regulators in Parkinson's Disease: PLA2G6 in lipid metabolism, mitochondria and synaptic transmission. KU Leuven
This doctoral project is being carried out in the neuronal communication lab and wants to do research on master regulators in Parkinson's disease: research of PLA2G6 in lipid metabolism, mitochondria and synaptic transmission.
Statistical methodology for epidemiological and clinical research in childhood and maternal health in the context of mother to child transmission of HIV and other infectious diseases Hasselt University
Novel approaches to prevent transmission of mitochondrial diseases: filling in the safety gaps towards clinical application Ghent University
Nuclear transfer (NT) is a newly proposed procedure in assisted reproductive technology, involving the transfer of the nuclear genome from a patient’s diseased oocyte or zygote to a donor’s healthy, enucleated counterpart. This approach has been suggested for preventing the transmission of mitochondrial DNA (mtDNA) diseases, which can lead to incurable and life-threatening conditions.
The current first line treatment ...