Targeting the androgen receptor dimerisation via computer-aided drug design and high throughput synthesis for prostate cancer therapy. KU Leuven
Inhibition of the androgen receptor is the most important strategy for treatment of advanced prostate cancer. While several drugs targeting this receptor are already in the clinic, they all share a common chemotype and mechanism of action, as well as suffer from resistance mutations. Therefore there is a need for a new approach such as the inhibition of the dimerisation of the receptor which is essential for its functioning. This can be ...