Solubilization of flurbiprofen with non-ionic Tween20 surfactant micelles: A diffusion 1H NMR study Research Institute for Agriculture, Fisheries and Food Ghent University
The diffusional behaviour of solubilized flurbiprofen (a poorly water soluble anti-inflammatory drug) in the presence of non-ionic Tween20 micelles was studied in an acidic environment (pH 3) using 1H NMR. Two different concentrations of flurbiprofen were considered, each at temperatures ranging from 15 to 55 °C. The variability of the hydrodynamic micellar diameter, which was calculated from diffusion 1H NMR data, revealed a structural ...