Achiral and chiral targeted brain metabolomics in volume-limited samples: quest for broad coverage, sensitivity and throughput using chemical derivatization and miniaturized liquid chromatography tandem mass spectrometry. Vrije Universiteit Brussel
To gain more information on all metabolites in the mouse brain
extracellular fluid and their role under physiological and
pathophysiological conditions, sensitive, selective and highthroughput LC-MS/MS methods that enable the quantification of a
broad range of neurochemicals are needed. Moreover, stereospecific
analysis of chiral amino and hydroxy acids is important as also the
minor enantiomers have been shown ...
extracellular fluid and their role under physiological and
pathophysiological conditions, sensitive, selective and highthroughput LC-MS/MS methods that enable the quantification of a
broad range of neurochemicals are needed. Moreover, stereospecific
analysis of chiral amino and hydroxy acids is important as also the
minor enantiomers have been shown ...