Projects
Understanding triple negative breast cancer dependence on serine biosynthesis: new insights for targeted therapy. KU Leuven
Breast cancer is the second leading causes of cancer death among women. This issue is of particular relevance for Belgium, which has the highest incidence rate for breast cancer in Europe. Today we know that breast cancer is no single disease. Conversely, multiple subtypes exist, with different molecular basis, clinical outcomes and response to treatment. The challenge we face is therefore to understand the characteristics of each breast ...
Quantitative Risk Management under Scenario Constraints: Risk aggregation, Dependence, and Systemic risk Vrije Universiteit Brussel
Reliable methods for analysing and managing the sources of dependence between financial assets at all frequencies Vrije Universiteit Brussel
Dependence Concepts, Stein's Identity and Conditional Expectation: A Theoretical Analysis and Exploration of Applications in Finance and Insurance Vrije Universiteit Brussel
Path dependency of population and community dynamics in heterogeneous landscapes: a theoretical and statistical approach KU Leuven
Understanding the processes that drive the distribution of genes and species in heterogeneous landscapes is a central goal in biology. However, the proportion of the patterns in gene or species distribution that can be explained is often limited. Path dependency results in historical contingencies in current-day patterns and might partly be responsible for our limited capacity to explain gene and species occurrences. In the proposed research, ...
Screening for drivers and dependency factors in a novel genetic model for T-ALL in Xenopus tropicalis Ghent University
Acute lymphoblastic leukemia (ALL) is an aggressive tumor entity of highly proliferative malignant
lymphoid cells. This leukemia subtype is one of the most common childhood malignancies
worldwide. T-ALL is a particularly aggressive hematologic cancer resulting from the malignant
transformation of T-cell progenitors. Despite our good and improving understanding of the
genomic defects in human T-ALL, leukemia patients ...
On the dependency between risks, with applications to the valuation of combined financial-actuarial risks in incomplete markets. KU Leuven
In his PhD work, the candidate will study dependency concepts between random variables, representing financial, actuarial or combined contingent claims. These claims might be traded (bought and sold) in a financial (arbitrage-free) market, they might be part of an insurance portfolio, or, in the more general case, they might consist of a combination of traded and insured claims. This research builds further on the expertise on dependency ...
Late life care transitions: How to cope meaningfully with increased dependency and need-for-care in late life KU Leuven
We live in an ageing society. Life expectancy significantly increases and final stage of life is prolonged. This prolongation, however, often implies a confrontation with increased dependency and need for care and triggers the self-view of the elder person. To become dependent on professional support and assistance in daily living can be considered a challenging turning point. We know from earlier research that making a transition to more ...
Unraveling the Motivational and Emotional Mechanisms Underlying the Relationship Between Dependency, Self-Criticism, and Adolescent Depression Ghent University
Dependency and self-criticism represent personality dimension involving vulnerability to depression. It is examined whether this vulnerability is accounted for by frustration of the basic psychological needs for autonomy, competence, and relatedness. Need frustration would generate stress which, in turn, would increase the risk for depressive symptoms. The hypotheses are examined in a series of longitidunal, diary, and experimental ...