Projects
Studying the mechanisms of developmental delay in KCNQ2 encephalopathy using patient derived brain organoids. University of Antwerp
Fundamental advances for the fire safety of tall timber structures including the fire decay phase Ghent University
Urban densification, sustainability drivers and technological advances foster the development of high-rise structures using bio-based materials like engineered wood products. Their main worldwide barrier relates to fire safety. Although a natural fire has a decay phase, structural capacity is traditionally assessed according to a standard fire curve: an unrealistic ever-increasing thermal exposure with time, conceived as worst-case design ...
Merging Excited State Decay Rate Theories with Semi-Classical Nonadiabatic Excited State Dynamics (PhotoSynergy) KU Leuven
Mechanobiology control of immunogenic cell death by bio-polymers for cancer therapy Ghent University
Immunogene celdood (ICD) combineert het vermogen om zowel kankercellen te doden als tegelijkertijd anti-tumorimmuniteit te activeren, en impliceert ferroptose, wat een efficiënte antikankerstrategie representeert. Eén van de belangrijkste knelpunten voor ferroptose en andere ICD-modaliteiten is de effectieve inductie van opname van stervende kankercellen die ICD ondergaan door fagocyten. In ongepubliceerd onderzoek waarbij een nieuw en ...
Understanding the vulnerability of the ageing heart KU Leuven
Density functional theory for unusual electronic structures KU Leuven
Smart algorithms for wearables to reduce relapse into stress related disorders KU Leuven
To date, depression is the worldwide leading cause for disability and a considerable contributor to the global disease burden. In recent years, another disorder that shares certain traits with depression has been on the rise, namely burnout. Although the prevalence and disease burden of burnout is not nearly as great as that of depression, it has been escalating in the last decade. As a result, burnout has been receiving a lot of attention in ...
Understanding Drug-Induced Cholestasis: Mechanistic exploration of hepatic bile acid disposition KU Leuven
Drug-induced liver injury (DILI) is the most frequent reason for drug withdrawal from the market (Xu et al., 2004; Atienzar et al., 2016). Hence, DILI poses a major risk for patient health and pharmaceutical industry. Nowadays, pharmaceutical industry is still confronted with the poor prediction of DILI in non-clinical safety environment during drug development. The current non-clinical in vivo animal tests are not ...
Population Balance Model-Based Optimization of Deracemization Processes for Pharmaceutical Applications KU Leuven
Chirality has different implications in pharmaceuticals, as in some cases, enantiomers exhibit different biological activities and most of the times, only one enantiomer (eutomer) possesses the desired effect. For example, ibuprofen, which is sold as a racemate (1:1 mixture of the two enantiomers R- and S-) under the trade names Advil, Motrin etc. is a drug able to treat pain, fever and inflammation. Even if only the S- enantiomer is ...