Projects
Replicative stress induced DNA damage response signaling at the crossroad between embryonic stem cells and MYC(N) driven tumours Ghent University
Embryonic stem cells (ESCs) have opened the way to the development of regenerative medicine
(cell therapy). For obvious reasons, preserving the integrity of their genome to avoid cancer
formation is of utmost importance. One possible cause for DNA damage is stress that occurs during
DNA replication (replicative stress). Interestingly, molecular evidence for this process has been
detected in both embryonic stem cells as ...
Minimizing the radiation damage in Ni-Ti-based TEM samples prepared by ion milling techniques. University of Antwerp
Synergistic drug interactions with CDK12-controlled DNA damage response signaling as potential therapy for high-risk neuroblastoma Ghent University
Neuroblastoma is a pediatric tumor originating from the sympathetic nervous system responsible for 10-15% of all childhood cancer deaths. Half of all neuroblastoma patients present with high-risk disease and nearly 50% relapse and die of disease. In addition, cytotoxic standard therapies cause serious lifelong side-effects including growth retardation, delayed cognitive development, infertility and increased risk for secondary tumors. Options ...
Preclinical evaluation of synergistic drug interactions with CDK12-controlled DNA damage response signaling as potential therapy for high-risk neuroblastoma Ghent University
Neuroblastoma is a pediatric tumor of the sympathetic nervous system associated with poor survival in high-risk cases. Current options for targeted therapy for high-risk neuroblastoma patients are limited and single compound strategies almost invariably fail due to escape mechanisms, driven either by initial tumor heterogeneity or through adaptive (epigenetic) responses or mutations. Consortia such as SIOPEN and ITCC (www.itcc-consortium.org) ...
Strategies to Avoid Electrically Induced Bearing Damage (EBeardam) KU Leuven
Strategies to Avoid Electrically Induced Bearing Damage
Damage identification in composite materials using Machine Learning techniques for Structural health monitoring Ghent University
Adipose tissue expandability and dysfunction: modulator of liver damage and disease progression in NAFLD? University of Antwerp
Functional characterization of the DNA damage response regulators CK2 and SOG1 under phosphate deficient conditions in Arabidopsis and maize Ghent University
Phosphate (P) limitation is a widespread abiotic stress, profoundly impacting crop yield. Breeding low P-tolerant crops is therefore a priority request for world agriculture. One outspoken effect of P deficiency is the loss of the root stem cells, resulting in meristem exhaustion. Recently, the host lab demonstrated that the DNA damage response (DDR) regulators CASEIN KINASE 2 (CK2) and SUPPRESSOR OF GAMMA RADIATION1 (SOG1) control the loss ...
Exploring the occurrence of foetal DNA damage after in utero exposure to chemotherapy - CURIOUS KU Leuven
Though rare, cancer in pregnancy is becoming more frequent due to the trend to postpone pregnancies until a later age. In large-scale clinical studies, we showed that chemotherapy given during pregnancy has no adverse effect on the short-term health of the infants. Yet, these children appear to be more often small for their gestational age, have a lower verbal IQ and increased chance of wearing glasses at the age of 6. Long-term health ...