Projects
The role of innate immunity in chronic intestinal inflammation and fibrosis: towards a cure for Inflammatory Bowel Disease? KU Leuven
The inflammatory bowel diseases (IBD), Crohn’s disease (CD) and ulcerative colitis (UC), are chronic relapsing and remitting inflammatory disorders of the gastrointestinal tract, presenting mostly in young adults (peak age of onset 15-30 years). The clinical course of IBD is highly heterogeneous and until now unpredictable. Due to recurrent flares, interspaced with periods of remission, cumulative remodeling of the gut wall occurs and this ...
Interplay between the endoplasmic reticulum, Ca2+ and autophagy induced by various stressors KU Leuven
Autophagy is an evolutionary conserved degradation process responsible for the removal of superfluous or damaged proteins and organelles. Autophagy maintains cellular health during stress conditions like nutrient or growth-factor depletion and is implicated in many diseases like cancer and neurodegeneration. The endoplasmic reticulum (ER), the major organelle for protein and lipid synthesis and for intracellular Ca2+ storage, plays a central ...
Does it all start with a head impact? Biomechanical analysis of post-traumatic neurodegenerative diseases KU Leuven
Neurodegenerative diseases form a large health problem worldwide for which currently no treatment exists. Neurodegeneration is related to the spreading of toxic misfolded proteins (prions) through the brain, causing cell death. Lots of studies have approached this complex problem from a clinical, biological or molecular point of view, but the mechanisms behind the development of these diseases are still poorly understood. This project will ...
A multidisciplinary study for the exploitation of biodegradable nanocarriers for targetted drug delivery to preterm newborn lungs KU Leuven
Aligning Fibre Break Models for Composites with the Observable Micro-Scale Material Behaviour KU Leuven
Continuous fibre reinforced polymer composites offer tremendous opportunities to address the need for strong yet lightweight structural parts for a wide variety of applications. Due to their intrinsic multi-phase makeup, their failure is not straightforward to predict as the behaviour of each of its constituents needs to be considered. While multiple different damage modes exist in laminates made of plies with different fibre orientations, ...
Metox: Metal oxalates in 15-16th century Netherlandish oil paintings Royal Museum of Fine Arts Antwerp
Metox: Metal oxalates in 15-16th century Netherlandish oil paintings Royal Museum of Fine Arts Antwerp
Metal oxalates in 15-16th century Netherlandish oil paintings (METOX) University of Antwerp
Towards the Development of Novel Cladding Materials based on Nanolaminated Ternary Carbides (MAX phases) for Different Nuclear Systems KU Leuven
After the Fukushima Daiichi accident, the interest in novel materials to improve nuclear safety and fuel cladding performances not only during service conditions but also in accident scenarios increased. For light water reactors (LWR) such as the Fukushima Daiichi reactor, the accident tolerant fuel (ATF) concept was developed to increase the coping-time during an accident by increasing oxidation resistance of the clad materials while ...